• Curcumin is a polyphenol extracted from turmeric which is co

  2019-11-13

  

  Curcumin is a polyphenol extracted from turmeric, which is commonly used as a spice and food-coloring agent in many cultures [9]. Curcumin possesses anti-inflammatory, antioxidant, and cancer-preventive properties [10], [11], [12]. In addition to these well-known effects, consuming curcumin may bene

• EC barrier dysfunction triggered by inflammatory mediators

  2019-11-13

  

  EC barrier dysfunction triggered by inflammatory mediators involves more than one mechanism, explaining the partial attenuation of EC barrier compromise obtained with PKA and Epac activators. PKA-dependent phosphorylation of vasodilator-stimulated phosphoprotein (VASP) has been shown to make a posit

• The Penicillium strain used in this work was isolated

  2019-11-13

  

  The Penicillium strain used in this work was isolated from Atlantic forest soil and previously screened as lipase producer (Tauk-Tornisielo et al., 2005). The immobilization was previously evaluated using hydrophobic supports, i.e. agarose based butyl-(But), phenyl-(Phe) and octyl-Sepharose (Oct), a

• In vasculature NADPH oxidases NOXs are the

  2019-11-13

  

  In vasculature, NADPH oxidases (NOXs) are the main sources of O2− generation that involve in the transfer of electrons to molecular oxygen. Endothelin-1 [25] and thromboxane A2 [26] were reported to induce eNOS uncoupling via upregulation of NOXs. Additionally, inhibition of p47 phox, a subunit of N

• For statistical analysis the Statistical Package

  2019-11-13

  

  For statistical analysis, the Statistical Package for Social Sciences (SPSS) was used (version 21.0; SPSSInc., Chicago, IL). Chi-square (x2) exact test was used for the comparison of categorical data, whereas Wilcoxon and Mann–Whitney U tests were used for the analysis of nonparametric variables bas

• Several functions of FAT have been suggested It has been

  2019-11-13

  

  Several functions of FAT10 have been suggested. It has been shown that FAT10 binds noncovalently to the mitotic spindle checkpoint protein MAD2 and that this binding might cause chromosome instability in the cancer iox mg overexpressing FAT10 (Liu et al., 1999, Ren et al., 2006). In other studies,

• br Conclusion The role of DNA PK target in DNA

  2019-11-13

  

  Conclusion The role of DNA-PK target in DNA DSB repair renders this VUF 11207 fumarate kinase of great medicinal interest in cancer chemotherapy especially the cancer types of linked to DNA defects. Due to the absence of 3D DNA-PK target structure, different ligand-based methods were applied for

• Introduction Maintenance of genome integrity is essential fo

  2019-11-13

  

  Introduction Maintenance of genome integrity is essential for life, and faithful DNA replication and repair ensure this. One of the most important parameters for DNA maintenance is the regulation of optimal concentrations of the four 5′-deoxyribonucleoside-triphosphates (dNTPs) the precursors for D

• In general the DNMT encompass three different structural reg

  2019-11-13

  

  In general, the DNMT encompass three different structural regions: N-terminal regulatory domain, C-terminal catalytic domain and a central linker region (). The N-terminal regulatory domain is particularly implicated in determining subcellular localization of the DNMT and in allocating unmethylated

• Nowadays colorimetric assay has been applied

  2019-11-13

  

  Nowadays, colorimetric assay has been applied in detecting DNA MTase activity. Li et al. used DNA modified gold nanoparticles (AuNPs) coupled with enzyme-linkage reactions to detect the activity of methylases [20]. In a previous study, our group presented a label-free colorimetric method, using unmo

• Azidobutyric acid NHS ester br As mentioned above defects in

  2019-11-13

  

  As mentioned above, defects in the DNA ligase IIIα-interacting protein TDP1 have been identified as the cause of the hereditary neurodegenerative disease, spinocerebellar ataxia with axonal neuropathy 1 (El-Khamisy et al., 2005). In addition, defects in two other DNA repair proteins, aprataxin and

• BIBR-1048 With regard to the DGATs we

  2019-11-13

  

  With regard to the DGATs, we have found that the majority of algal species encode at least one DGAT1, although it appears to be absent from Ostreococcus and Micromonas, as is the case for yeast, S. cerevisiae. More surprising is the presence of multiple DGAT2 genes in algae, with the exception of C.

• 3-CPMT br Materials and methods br Results

  2019-11-12

  

  Materials and methods Results Recombinant, N-terminally His6-tagged vCPH was purified to near homogeneity via a modification of the reported procedure and its identity confirmed by intact protein mass spectrometry (Supplementary Fig. 1). As reported, vCPH catalysed two hydroxylations of a PAPK

• br Patients and methods br Results Table shows relevant

  2019-11-12

  

  Patients and methods Results Table 1 shows relevant demographic and clinical characteristics of the 123 patients in the cohort. BAL fluid samples were obtained at a median of 172.5 days after allo-HSCT (range 3 days to five years). Discussion The definitive abandonment of traditional cultu

• Cinacalcet HCl receptor The same reservoir of genes is invol

  2019-11-12

  

  The same reservoir of Cinacalcet HCl receptor is involved in fusions in all types of cancers, which predominantly encode kinases and transcriptional factors [102]. This makes fusion genes potential pan-cancer targets, and renders tumor categorization based on genetic profiling therapeutically reaso

15460 records 898/1031 page Previous Next First page 上5页 896897898899900 下5页 Last page