• Sex has been shown to mediate the relationship

  2020-03-10

  

  Sex has been shown to mediate the relationship between allelic differences in COMT and behavior (Harrison & Tunbridge, 2008). The COMT promoter region contains 2 estrogen response elements (Xie, Ho, & Ramsden, 1999) that can inhibit the formation of COMT (Jiang, Xie, Ramsden, & Ho, 2003). With regar

• br Significance Our understanding of the

  2020-03-10

  

  Significance Our understanding of the ubiquitin biology has been rapidly expanding. The role of the ubiquitin system in the pathogenesis of numerous disease states has increased the interest in finding new strategies to pharmacologically interfere with the enzymes responsible of the ubiquitinatio

• br Conclusion The role of DNA PK

  2020-03-10

  

  Conclusion The role of DNA-PK target in DNA DSB repair renders this (-)-Bicuculline methiodide kinase of great medicinal interest in cancer chemotherapy especially the cancer types of linked to DNA defects. Due to the absence of 3D DNA-PK target structure, different ligand-based methods were appl

• br Development of the double strand break repair model

  2020-03-10

  

  Development of the double strand break repair model for meiotic recombination Meiotic recombination was first described by Frans Alfons Janssens using Ac-Endothelin-1 (16-21), human in the salamander Batracoseps attenuatus in 1909 [21] and then further elaborated at the genetic level in Drosophil

• br Cysteine proteases as molecular targets for

  2020-03-10

  

  Cysteine proteases as molecular targets for trypanosomatid diseases Approaches relying on a molecular target, such as SBDD and target-based screening, have supported outstanding scientific developments in current pharmaceutical R&D. By integrating experimental and computational methods, these str

• Recently we have demonstrated that the synthesis of

  2020-03-10

  

  Recently we have demonstrated that the synthesis of cysteinyl-LTs from LTA4 by human umbilical vein endothelial cells (HUVECs) is directly associated with the activation of the CysLT2 receptor (CysLT2R) in a typical autocrine fashion, and that solely the CysLT2R is responsible for the increase in in

• In previous works Gotor Vila et al c differences in

  2020-03-10

  

  In previous works (Gotor-Vila et al., 2017c), differences in solubility between the two carriers used during formulation were evidenced. Summarizing, maltodextrin (BA3 product) resulted in a much more soluble product since this polysaccharide is typically composed of an amount of reducing sugars bet

• The GH family includes also xylanases which are

  2020-03-09

  

  The GH30 family includes also xylanases which are not MeGlcA-dependent. Most of them are grouped to GH30_7 subfamily that includes XynIV from Trichoderma reesei showing exo- and endo-xylanase activity [11] and XYLD from Bispora sp. MEY-1 [12] having activity towards glucuronoxylan and arabinoxylan,

• It is noteworthy that little

  2020-03-09

  

  It is noteworthy that little is known as to the role of autophagy in regulation of eNOS phosphorylation and eNOS uncoupling. eNOS monomers, but not eNOS dimers could be degraded by ubiquitination [39], harbingering the existence of protein degradation pathways in modulation of eNOS turnover and acti

• PKA signalling in the nucleus was thought to be due

  2020-03-09

  

  PKA signalling in the nucleus was thought to be due to the translocation of the catalytic subunit upon activation from the Ki8751 receptor to the nucleus via diffusion [72]. However, a new understanding has emerged, as both the regulatory and catalytic subunits have been identified in the nucleus an

• br Results br Discussion It

  2020-03-09

  

  Results Discussion It has been thought that commitment to the plasma cell fate begins while adenylate cyclase are still in the GC (Suan et al., 2017, Victora and Nussenzweig, 2012), but the main obstacle to test this model and, if correct, to clarify how the plasma cell-prone GC cells develop

• br Results br Discussion It

  2020-03-09

  

  Results Discussion It has been thought that commitment to the plasma cell fate begins while A-317491 are still in the GC (Suan et al., 2017, Victora and Nussenzweig, 2012), but the main obstacle to test this model and, if correct, to clarify how the plasma cell-prone GC cells develop has been

• Moreover the imbalance between pro and anti inflammatory cyt

  2020-03-09

  

  Moreover, the imbalance between pro and anti-inflammatory cytokine production is present in various types of diseases. The use of substances able to induce anti-inflammatory cytokines could represent an important advance in the therapeutic treatment of a range of diseases. In this context, medicinal

• Other karyopherins besides CRM must bind to

  2020-03-09

  

  Other karyopherins besides CRM1 must bind to FG-Nups in a similar fashion. However, at an atomic resolution, only the interaction of importin β with isolated FG motifs has been analyzed (Bayliss et al., 2000, Bayliss et al., 2002, Liu and Stewart, 2005). Despite similarities in the FG-binding pocket

• While we are taking full

  2020-03-09

  

  While we are taking full responsibility for any remaining errors and shortcomings of the paper, we would like to thank Dr. Jong-Hyeon Jeong, Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, for offering us insight and literature pointers useful in our quest to

15862 records 862/1058 page Previous Next First page 上5页 861862863864865 下5页 Last page