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It has been shown that DAPK induces cell death
2021-05-14
It has been shown that DAPK induces cell death through an increase in DAPK catalytic activity and subsequent phosphorylation of target proteins (Shang et al., 2005, Yamamoto et al., 2002), but its multidomain structure enables also a close physical interaction with other proteins (Bialik and Kimchi,
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Rottlerin We hypothesized that the atopic phenotype
2021-05-14
We hypothesized that the atopic phenotype may be partially influenced by an altered binding and/or signalling due to the amino-acid substitution in the receptor protein. The principal aim of this study was to investigate the signalling mechanisms of the variants CysLT1-G300S and CysLT1-I206S induced
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A cocktail approach can detect the activities of multiple
2021-05-14
A cocktail approach can detect the activities of multiple CYP 450 isoforms following administration of multiple CYP-specific substrates in a single experiment. Caffeine, losartan, omeprazole, dextromethorphan and midazolam are often used as substrates in “cocktail probes” of human cytochrome CYP1A2,
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In agreement with the study
2021-05-14
In agreement with the study on porcine microsomes (Ekstrand et al., 2015), our results indicated a somewhat higher degree of inhibition of CYP2E1 activity in the male pools compared to females. Nevertheless, the degree of this compound libraries for drug discovery kinase inhibitor inhibition did no
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br Introduction Alzheimer s disease AD is the progressive ve
2021-05-14
Introduction Alzheimer’s disease (AD) is the progressive version of mild cognitive impairment and usually met by the elderly population. It falls into the class of neurodegenerative disorders that attacks the benzydamine synthesis nerves cells, or neurons, resulting in loss of memory, impairment
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Fig shows graphically the abundance
2021-05-14
Fig. 3 shows, graphically, the abundance distributions of the ARD% of the investigated data with both the CPA-NRTL and CPA-UNIQUAC models, where ARD% is defined as,in which x and x are the experimental and calculated SO2 molar compositions in the liquid phase, respectively, and N is the total number
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Following the relationship model adopted in this work
2021-05-14
Following [20], [22], the relationship model adopted in this am680 work to estimate the time to failure is the Inverse Power Law (IPL): Where L is the SUT life characteristic (e.g. the mean time to failure), s represents the stress level, while k and w are model-related parameters to be defined fro
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Notably HSP expression is under
2021-05-14
Notably, HSP27 expression is under control of the tetrameric form of CK2 holoenzyme, as knockout or knockdown of the β regulatory subunit alone reproduces the same effects of targeting the α/α′ catalytic subunits. This observation discloses the possibility to use more specific drugs that affects onl
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Several TERRA binding proteins have also been discovered esp
2021-05-14
Several TERRA-binding proteins have also been discovered, especially telomeric duplex DNA binding proteins TRF1 and TRF2, pointing to a significant role of TERRA in more general chromosome biology [14], [20], [21]. TRF2 is a key component of Shelterin that protect chromosome termini [22]. Telomeres
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Introduction Angiotensin II Ang II
2021-05-14
Introduction Angiotensin II (Ang II) and Endothelin 1 (ET-1) are potent vasoconstrictive peptides recognized as key players in many cardiovascular diseases [1]. Cardiac hypertrophy, ischemic arrhythmia, and stroke have been associated to an overstimulation of the angiotensin II type 1 (AT1) recepto
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br Experimental Procedures br Author Contributions br Acknow
2021-05-14
Experimental Procedures Author Contributions Acknowledgments We thank the Mouse Modeling, Integrated Microscopy, and FACS Facilities of IGB-CNR, Naples. Dr. Laura Pisapia is acknowledged for flow cytometry analyses. We are grateful to Prof. Chris Ponting and George A. Calin for insightful s
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Since OH PGE is a moderately
2021-05-14
Since 1-OH-PGE2 is a moderately selective EP4 agonist which could bind to mouse EP3 and EP4 with a relatively similar affinity (Kiriyama et al., 1997), we have used a highly selective EP4 agonist CAY10580 to evaluate the involvement of EP4 activation in PGE2-facilitated EP4 internalization and recyc
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The contribution of local ETA and ETB receptors towards heat
2021-05-14
The contribution of local ETA and ETB receptors towards heat hyperalgesia induced by inoculation of XC tumor CC-4047 in the paw of mice has been demonstrated by Baamonde and colleagues (Baamonde et al., 2004). Furthermore, using neuropathic and inflammatory nociception models, several studies have s
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br DDR mediated signaling DDRs initiate signaling pathways i
2021-05-14
DDR-mediated signaling DDRs initiate signaling pathways in a context and cell type-dependent manner. For instance, DDR1 was reported to activate ERK in vascular smooth muscle Mycophenolate Mofetil (Lu et al., 2011), to inhibit ERK in mesangial cells (Curat and Vogel, 2002), and to have no effect
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br Conclusion The present study is
2021-05-14
Conclusion The present study is the first to provide in vivo evidence that the σ1R deficiency can cause age-related increases in aggregation and phosphorylation of αSyn in dopaminergic neurons of SNpc. The σ1R has been reported to be decreased in the Z-YVAD-FMK region of the nigrostriatal dopami
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