• Despite the importance of intratumor phenotypic heterogeneit

  2021-10-29

  

  Despite the importance of intratumor phenotypic heterogeneity for tumor progression and therapy resistance (Marusyk et al., 2012, Marusyk and Polyak, 2010), our understanding of regulators of this process and our ability to modulate them are very limited. Recent advances in genomic sequencing and si

• br Acknowledgments We thank Prof Alexander D

  2021-10-29

  

  Acknowledgments We thank Prof. Alexander D. Johnson and Suzanne M. Noble for kindly providing SN strains. This work was supported by Chinese National Natural Science Foundation Grants 31370105 and 31300057, and Shanghai STCSM Grant 12JC1409300. Introduction Organisms modulate gene expression

• br Conclusion Our data allow pharmacological discrimination

  2021-10-29

  

  Conclusion Our data allow pharmacological discrimination of diverse of H3 FITC, Fluorescein isothiocyanate antagonists that can be linked to their differential efficacy in preclinical and clinical disease settings (Fig. 6). Moreover, we identify the sigma-1 receptor as a common “off target” for H

• Tadalafil Wolf et al then proceed to interrogate the mechani

  2021-10-29

  

  Wolf et al. (2016) then proceed to interrogate the mechanism by which NAG activates the NLRP3 inflammasome. When examining potential triggers previously implicated in NLRP3 activation, they found that both PGN and NAG trigger appearance of mitochondrial DNA (mtDNA) in the cytosol, which led them to

• Recently it has been found

  2021-10-28

  

  Recently, it has been found that treatment of human phagocytic Vancomycin hydrochloride or microvascular endothelial cells with NO donors inhibited the O2− generating capacity of NADPH oxidase [[8], [9], [10], [11]], which may involve down-regulation or S‑nitrosylation of the p47phox subunit (a cyt

• Studies utilising GPR mice however report

  2021-10-28

  

  Studies utilising GPR55−/− mice, however, report different effects of GPR55 on body weight and insulin sensitivity. Genetic deletion of GPR55 appears to have no effect on overall body weight 5, 6, 7. However, one of these studies found increased fat deposition and insulin resistance in GPR55−/− mice

• SGCs tightly ensheath the soma of

  2021-10-28

  

  SGCs tightly ensheath the soma of DRG neurons (Costa and Moreira, 2015, Hanani, 2005, Takeda et al., 2009). Intimate associations between SGCs and neurons facilitate bidirectional regulation of SGC function and neuronal excitability. After nerve injury, neuronal hyperexcitability can result in SGC a

• ITD 1 The mechanisms by which NEIL and NEIL

  2021-10-28

  

  The mechanisms by which NEIL1 and NEIL3 excise bulky adducts and unhook ICLs are unclear. Structures of NEIL1 are available only in complex with DNA containing small lesions 79., 80., 81., and the single available structure of NEIL3 lacks DNA (Figure 5D,E) [73]. Nonetheless, comparison of the two st

• br Transporter based brain targeting nano DDS Drug

  2021-10-28

  

  Transporter-based brain-targeting nano-DDS Drug delivery to the central nervous system (CNS) is still challenging due to the bloodbrain barrier (BBB)53., 54.. The BBB is a natural defense barrier protecting the ACP-196 from harmful substances. Since only selected, neutral, lipophilic small molec

• In order to discover novel

  2021-10-28

  

  In order to discover novel small-molecule compounds with the activity of GLUT4 translocation, we conducted a cell-based phenotype screening in L6-GLUT4-myc myoblasts by measuring appearance of GLUT4 on the plasma membrane (GLUT4 translocation activity). Evaluation of total 183,400 compounds gave sev

• br Acknowledgments br Introduction Postmenopausal osteoporos

  2021-10-28

  

  Acknowledgments Introduction Postmenopausal osteoporosis, which is primarily caused by natural 5 alpha reductase inhibitors deficiency, has been a worldwide health problem and threatens postmenopausal women of all races. An estimated 80% of osteoporosis patients in the United States are women

• br Presenilins and apoptosis Apoptosis also known

  2021-10-28

  

  Presenilins and apoptosis Apoptosis, also known as programmed cell death, has a critically important role in tissue homeostasis, development, normal ageing and the pathogenesis of several diseases, including cancer and neurological disorders. The presenilins were first linked to apoptosis when ce

• ER 50891 Another lever to efficiently eradicate tumors inclu

  2021-10-28

  

  Another lever to efficiently eradicate tumors including ovarian cancer might rely on their high addiction to iron [34]. In fact, ultrasmall silica-based nanoparticles, functionalized with melanoma-targeting peptide, efficiently triggered ferroptosis not only in cell culture but also in tumor bearing

• In addition to the regulation of SV exo and endocytosis

  2021-10-28

  

  In addition to the regulation of SV exo- and 6-Bnz-cAMP sodium salt by Ca2+ influx retrieval of SV membranes depends on the exocytic insertion of SV components into the presynaptic membrane: If exocytic SV fusion in neurons is abrogated by genetic inactivation of the core release machinery (e.g. kno

• Polyunsaturated fatty acid components of brain are more pron

  2021-10-27

  

  Polyunsaturated fatty chlortetracycline components of brain are more prone to oxidative attack, an event called lipid peroxidation. Consistent with previous findings on neurotoxicity [58,59], colistin sulphate increased the level of MDA in the brain of rats. The elevated MDA, a consequence of overw

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