aldehyde dehydrogenase inhibitor We speculate that ROS reduc

2018-10-20

We speculate that ROS reduction has an important, but not exclusive, regulatory role in the cAMP-mediated maintenance of HSC-like cells. Moreover, cAMP-mediated ROS/p38 reduction and increased CXCR4 receptor expression provide a correlational benefit to HSC-like cells, as low ROS levels specifically

mSSCs can be maintained and genetically manipulated

2018-10-20

mSSCs can be maintained and genetically manipulated in vitro over extensive periods, providing a valuable resource for in vitro studies of meiosis and post-meiotic development (Kanatsu-Shinohara et al., 2003; Kubota et al., 2004). In the past decade, this culture system has been used to identify key

miRNAs are known to regulate the expression

2018-10-20

miRNAs are known to regulate the expression of multiple targets via binding to 3′ UTR. Our finding that the miR-29 family regulates global DNA methylation and demethylation adds another role to the list of common regulatory roles of miRNAs. The miR-29 family was known to regulate ECM proteins in phy

3X FLAG tag Our results show that anterior NPCs can give ris

2018-10-20

Our results show that anterior NPCs can give rise to GnRH-expressing 3X FLAG tag when cultured with FGF8, which has been shown to promote progenitor cell survival in the anterior neural structures (Forni et al., 2013; Kawauchi et al., 2005). In mouse anterior neural ridge, FGF8 has been shown to po

br Experimental Procedures See also Supplemental Experimenta

2018-10-20

Experimental Procedures See also Supplemental Experimental Procedures. Author Contributions Acknowledgments We thank Dr. Yun Deng for providing Tg (myl7:EGFP) zebrafish, Dr. Niels C. Bols and Dr. Peng Hu for their technical support with zebrafish. This work was supported by the National Na

RPE cell associated allografts have been considered

2018-10-20

RPE cell-associated allografts have been considered for the treatment of ocular diseases such as age-related macular degeneration (AMD). We successfully established human RPE LY294002 from human iPSCs (Kamao et al., 2014; Sugita et al., 2015). In addition, we recently transplanted an iPSC-derived R

Hello world!

2018-07-29