• These data provide new insight into potential mechanisms by

  2018-11-14

  

  These data provide new insight into potential mechanisms by which CXCL10 contributes to demyelinating diseases. Early studies revealed that CXCL10 was produced in active lesions in patients with the demyelinating disease MS and CXCR3-positive T lymphocytes were enriched within the cerebral spinal fl

• Previously we reported a chemical genetic screen that reveal

  2018-11-14

  

  Previously, we reported a chemical genetic screen that revealed that several statins activate a β-catenin-responsive luciferase reporter (BAR) in a cell-based assay (Biechele et al., 2010). This result supports prior in vitro studies that have shown that statins modulate Wnt/β-catenin signaling (hen

• br Results br Discussion This work

  2018-11-14

  

  Results Discussion This work represents a number of important advances for the study of axolotl regeneration. First, we have shown for several genomic loci that TALENs and CRISPRs can induce targeted deletions in a large proportion of cells from injected animals. In all cases, CRISPRs yielded

• Implementation of MSCs in the

  2018-11-14

  

  Implementation of MSCs in the aspect of tissue-engineering has been shown to be apt in the synergism of cell biological and biomaterial technologies (Maruyama et al., 2016; Tan and Hung, 2017). The MSCs on integration with the current bio-scaffolds indeed prove to be reconstructive (Dehghanifard et

• br Experimental Procedures Detailed information on the exper

  2018-11-14

  

  Experimental Procedures Detailed information on the experimental procedures can be found in the Supplemental Information File. Author Contributions Introduction Although cell-fate decisions are fairly stable in vivo, somatic kinase inhibitors can be reprogrammed back into pluripotency in v

• We therefore set out to investigate whether mTORC

  2018-11-14

  

  We, therefore, set out to investigate whether mTORC1 inhibitors like rapamycin would be relevant for the generation of human TSCM histone demethylase inhibitor and whether a cross-talk between mTOR and Wnt signalling would exist. Moreover, since current knowledge on the generation and characterizati

• In acute cases of E coli

  2018-11-14

  

  In acute cases of E. coli diarrhea, the barrier function of the gut mucosa in the small intestine is compromised. When the pathogen is lysed by phage, in vivo released endotoxins and enterotoxins can thus potentially cross into the circulation. However, no systemic reaction to endotoxin was observed

• br Materials and Methods br Results br Discussion In

  2018-11-14

  

  Materials and Methods Results Discussion In the present population-based study, we assessed the relationship between pre-diagnostic Treg to tTL ratios and future cardiovascular events using a highly specific epigenetic assay for the quantification of T cell subsets. After a median follow-up

• br Funding Sources Research reported in this

  2018-11-14

  

  Funding Sources Research reported in this publication was supported by a grant from the Canadian Institutes for Health ResearchMOP-74493, the National Institute of Allergy and Infectious Diseases (NIAID) of the U. S. National Institutes of Health under Award Number R33AI098701, and the Intramural

• DNA methylation is a major epigenetic mechanism

  2018-11-14

  

  DNA methylation is a major epigenetic mechanism responsible for changing the program of genes thus deviating towards disease states (Lardenoije et al., 2015; Szyf et al., 2016). An increasing body of evidence indicates that predisposition to various neurological and psychiatric disorders are saved

• The rationale for use of FASN inhibitors as a key

  2018-11-14

  

  The rationale for use of FASN inhibitors as a key component of combination therapy derives from known cellular effects of FASN inhibition (Ventura et al., 2015; Chuang et al., 2011; Kridel, 2004; Puig et al., 2009, 2008; Tomek et al., 2011) that include (1) blockade of palmitate synthesis, (2) disru

• The findings of the studies included in these systematic

  2018-11-14

  

  The findings of the studies included in these systematic reviews and meta-analyses are notable for their consistency across countries, cultures and age groups. At their core, the many and varied versions of a ‘healthy’ diet comprise higher intakes of nutrient-dense plant based foods and quality sour

• SAMD appears to be a central mediator for

  2018-11-14

  

  SAMD appears to be a central mediator for interventions that extend healthy lifespan. Dietary restriction induces autophagy, improves mitochondrial function, specifically in complex I (Miwa et al., 2014) and reduces frequencies of senescent order Calcitriol in many tissues (Wang et al., 2010). Simi

• br Data Cross linking formaldehyde and denaturing ethanol

  2018-11-14

  

  Data Cross-linking (formaldehyde) and denaturing (70% ethanol and methanol/glacial acidic acid, 3:1, v/v) fixatives exert different effects on oocyte and NLB morphology (Fig. 1a, a′, a″), large-scale chromatin configuration (b, b′, b″) and on accessibility of the NLB material to immunofluorescenc

• br Bioinformatics analysis of the identified

  2018-11-14

  

  Bioinformatics analysis of the identified proteins To get a precise prediction, multiple bioinformatics methods were performed. First, the mouse TG101348 thus identified were associated with their putative human orthologs using NCBI׳s HomoloGene resource. Homogene annotations were downloaded fro

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