• Another question to address is the potential influence of th

  2018-10-24

  

  Another question to address is the potential influence of the degree of maturity of prepubertal donor tissue on the success of transplantation. Donor age-dependent differential gene expression and subsequent protein expression have been reported in tissue grafts. This could alter the initial ability

• The majority of the characterized NETs bind

  2018-10-24

  

  The majority of the characterized NETs bind lamins and/or chromatin binding proteins (Harr et al., 2016; Kind et al., 2013; Wong et al., 2014). Chromatin proteins in pluripotent stem mao inhibitor display hyperdynamic plasticity (Chen and Dent, 2014; Meshorer et al., 2006). During differentiation,

• Collectively we have evaluated the impact

  2018-10-24

  

  Collectively, we have evaluated the impact of a MODY5-causing point mutation (S148L) in the HNF1B gene on human pancreas development using a unique human stem cell model. We report molecular phenotypes (up- and down-regulation of pancreatic genes) when HNF1B is increasingly expressed from days 7 to

• The present study indicated that induction of glutamatergic

  2018-10-24

  

  The present study indicated that induction of glutamatergic markers by nucleotides involved the P2Y4-Gq signaling axis. Expression of the P2Y4 nucleotide receptor was transiently augmented in the course of neuronal differentiation of ESCs, which is coincident with the window of nucleotide-induced vG

• Previous reports have described ESC based differentiation

  2018-10-24

  

  Previous reports have described ESC-based differentiation in collagen gels to study the developmental events of vasculogenesis and angiogenesis (Feraud et al., 2001; Hermant et al., 2007). However, these were not optimized for the assessment of more fundamental aspects of vessel induction, patternin

• Traditionally testing of hPSC lines for gross chromosomal ch

  2018-10-24

  

  Traditionally, testing of hPSC lines for gross chromosomal changes employed karyology by chromosome banding of metaphase topotecan Supplier (Amps et al., 2011; Baker et al., 2007). Although karyotyping allows examination of the entire cell genome in a single assay, an often overlooked issue in eval

• When we compared the in

  2018-10-24

  

  When we compared the in vivo MaSC activity using the gold standard mammary fat pad transplant assay, we found the CD24+ CD49fhi SCA-1neg cells had higher stem cell activity than the CD24+ CD49fhi SCA-1+ subset. Although the stem cell activity of the CD24+ CD49fhi SCA-1+ cells was limited (in vitro m

• In summary our findings indicated that miR promoted the

  2018-10-24

  

  In summary, our findings indicated that miR-375 promoted the osteogenic differentiation of hASCs both in vitro and in vivo, and miR-375 targeted DEPTOR to inhibit the activity of AKT signaling during this process. Furthermore, YAP1 together with miR-375 established a negative feedback loop to regula

• There is a fast growing interest in

  2018-10-24

  

  There is a fast-growing interest in microglia, as they are increasingly implicated in neurodegenerative disease, neurodevelopmental disorders, and in neuropathic pain. Our iPSC microglia transcribe key ci-1033 involved in AD, PD, and MND. Several other disease-associated genes, including LRRK2, woul

• Study of microglia has been largely restricted to non human

  2018-10-24

  

  Study of microglia has been largely restricted to non-human models (mostly mouse), since availability of fresh primary human microglia is very limited and they cannot be propagated. Moreover, microglia rapidly lose their unique identity when removed from the ion channel environment and cultured in

• br After quantization the Laplace Beltrami operator where re

  2018-10-24

  

  After quantization, the Laplace-Beltrami operator where , replaces the quadratic form of the momenta (11). In this case, the “kinetic energy” operator has the form The first term in (14) is a “radial” part of the kinetic energy of the Universe similar to the radial part of the kinetic energy

• The triode system for the investigation of

  2018-10-24

  

  The triode system for the investigation of the layered cathodes emission characteristics is shown schematically in Fig. 4. Measurements of the field emission currents were carried out in pulsed mode (2 µs, 200 Hz). Fig. 4 shows the cathode system with three layered structures as an object. A pulse

• Fig illustrates the effect of the P clet number on

  2018-10-24

  

  Fig. 5 illustrates the effect of the Péclet number on the computational results, showing the time-averaged velocity magnitude fields for the three-row bundle at Pe = 600 and 1200. It can be seen that flow structures predicted by the URANS method for these regimes differ both within the tube bundle a

• There is evidence indicating literacy has a protective effec

  2018-10-24

  

  There is evidence indicating literacy has a protective effect on depressive symptoms (Barnes, Tager, Satariano, & Yaffe, 2004; Gordon, Hampson, Capell, & Madhok, 2002; Sudore et al., 2006). A randomized controlled trial of adults with depression and limited literacy demonstrated combining depression

• br Material and methods Our data come from the

  2018-10-24

  

  Material and methods Our data come from the 2004–2009 waves of the National Health Interview Survey (NHIS)-Sample Adult File (SAM). The NHIS is a large, nationally representative, cross-sectional survey that tracks the health of the non-institutionalized U.S. population, and has a response rate o

15343 records 1019/1023 page Previous Next First page 上5页 10161017101810191020 下5页 Last page