• Linsitinib br DGAT proteins lipid droplets and

  2019-07-03

  

  DGAT proteins, lipid droplets and cancer cells Conclusions and future directions Conflicts of interest Acknowledgements This work was supported by NIH grants GM062887, P01CA097132, and Veterans Affairs Merit Award to LMO. Introduction Bioethanol and biodiesel are regarded as the two

• br Introduction Alzheimer s disease AD is the

  2019-07-03

  

  Introduction Alzheimer’s disease (AD) is the progressive version of mild cognitive impairment and usually met by the elderly population. It falls into the class of neurodegenerative disorders that attacks the Proteinase K nerves cells, or neurons, resulting in loss of memory, impairment of thinki

• The present study found a significant

  2019-07-03

  

  The present study found a significant negative correlation between miR-152-3p and CDK8 expression in human HCC tissues. We also validated that CDK8 was a direct target of miR-152-3p, and overexpression of miR-152-3p inhibited proliferation and induced apoptosis in HCC hydroxycarboxylic acid receptor

• The aim of the present study was to

  2019-07-02

  

  The aim of the present study was to investigate the acute effects of THC on resting state 7α,25-dihydroxy Cholesterol weight neurophysiology, and to examine the impact of COMT genotype on these effects. Thirty-nine healthy volunteers participated in a randomised, placebo-controlled, crossover pharm

• agomelatine weight br Materials and methods br Results br Di

  2019-07-02

  

  Materials and methods Results Discussion One novel finding in our study is that CK2 inhibition preserved axon function and structure in WM against ischemia. Consistent with these findings, oligodendrocytes, astrocytes, myelin, and agomelatine weight were found to express CK2α. The robust ex

• br Introduction Abdominal aortic aneurysm AAA is a

  2019-07-02

  

  Introduction Abdominal aortic aneurysm (AAA) is a daily concern in vascular surgery, as successful treatment is exclusively achieved by open or endovascular repair. Its prevalence is 2–11% among male smokers, and rupture the major complication, is associated with unacceptably high morbidity and m

• T cell infiltration is an

  2019-07-02

  

  T cell infiltration is an important predictive biomarker for the PD-1 blockade, and it is closely associated with a good prognosis. In our study, we found that T cells were low and exhausted within the tumor microenvironment and were distributed in the tumor margin. Anti-PD-1 treatment reduced PD-1

• EPZ-6438 Compounds were screened for their activity against

  2019-07-02

  

  Compounds were screened for their activity against the hERG channel, with the 2,3-Cl compounds more active here than the 2,4-F compounds. The homopiperazine examples (, , , ) showed increased hERG activity relative to the corresponding piperazines. The cell data for the 6,7-dimethoxyquinoline compo

• SCR7 Estrogen treatment in postmenopausal women requires com

  2019-07-02

  

  Estrogen treatment in postmenopausal women requires combination with a progestogen in order to prevent endometrial stimulation. This is not necessary, however, with tibolone as progestogenic activity is associated with its Δ4-metabolite that is formed in the liver, as well as locally in the endometr

• br Discussion We are reporting a cryptic insertion of

  2019-07-02

  

  Discussion We are reporting a cryptic insertion of chromosome 22 material (EWS) to the long arm of chromosome 11 (11q24, FLI-1) recognizable by FISH in ursolic acid molecular exhibiting trisomy 8 as the sole cytogenetic anomaly. In ES and PNET tumors, trisomy 8 is the most common secondary abnor

• Current therapeutic protocols in OS and ES consist

  2019-07-02

  

  Current therapeutic protocols in OS and ES consist of neoadjuvant chemotherapy and local surgical resection, followed by adjuvant chemotherapy. These treatments lead to a 70% overall survival for localized disease but can decrease to 15% in case of metastasis. With CS being resistant to conventional

• Quantifying diffusion is greatly complicated by the ubiquito

  2019-07-02

  

  Quantifying Picroside II weight is greatly complicated by the ubiquitous unevenness of soil surfaces and related water films, which introduce a large uncertainty into size (area) and quality of contact between the soil surface and the membrane, the problem being particularly substantial in well aggr

• br Chondroitin sulfate proteoglycans CSPGs are major compone

  2019-07-02

  

  Chondroitin sulfate proteoglycans (CSPGs) are major components of the extracellular matrix in cartilage. Each CSPG comprises a single core protein and attached chondroitin sulfate (CS), belonging to the glycosaminoglycan family of sugar chains. CSPGs and CS are involved in numerous biological and

• A structured inherited arrhythmia or heart disease

  2019-07-01

  

  A structured inherited arrhythmia (or heart disease) clinic provides the platform for optimized multidisciplinary evaluation and management of patients and families with suspected inherited heart disease. The collective efforts of the core staff and access to a variety of experts in related discipli

• The patient had experienced cardiopulmonary arrest because o

  2019-07-01

  

  The patient had experienced cardiopulmonary arrest because of PEA and bradycardia at least twice while on oral treatment for variant angina, but neither ventricular fibrillation nor ventricular tachycardia was apparent. Spontaneous attacks occurred despite the use of an oral calcium blocker, and low

16019 records 1012/1068 page Previous Next First page 上5页 10111012101310141015 下5页 Last page